No.65 is a paramount topical filler designed to help your skin rebuild itself naturally from within. Instead of adding artificial volume, it stimulates your skin’s own collagen production to restore firmness, density, and a youthful appearance.
Powered by patented nano-sized Calcium Hydroxyapatite with an average size of 65 nm, No.65 uses one of the smallest CaHA particles available for optimal skin penetration. These advanced particles act as biological messengers that activate collagen production, support dermal structure renewal, and improve skin firmness without needles and without artificial volumizing effects.
By enhancing cellular activity and skin energy, No.65 supports natural repair processes that strengthen the skin over time for visibly denser, smoother, and more resilient skin with a refined texture and healthy radiance.
No.65 is ideal for skin that feels thinner, less firm, or shows visible signs of aging. It enhances overall skin quality through true biological renewal, delivering long-term improvement rather than temporary plumping
How It Works
Stimulates Collagen Production and Dermal Regeneration
Calcium ions released from nano-CaP activate the CaSR receptor on fibroblasts, up-regulating type I collagen synthesis and strengthening the dermal framework.
Enhances Cellular Energy and Metabolism
Phosphate ions support ATP synthesis, boosting cellular metabolism and optimizing the skin’s regenerative capacity.
Promotes ECM Remodeling
Direct nanoparticle interaction with keratinocytes and fibroblasts enhances extracellular matrix organization, leading to progressive skin densification and smoother texture.
Provides Long-Term Bio-Stimulation
The nano-delivery system ensures controlled, sustained activation of regenerative pathways for continuous improvement in skin quality.
Benefits
-
Stimulates physiological collagen production and dermal regeneration
-
Improves skin density, firmness, and elasticity
-
Enhances skin texture and surface smoothness
-
Provides regenerative and optical skin-enhancing effects
-
Visible collagen remodeling within 6–8 weeks
-
Densifies skin without volumizing or adding bulk
Show Less