In recent years, skin-healing ingredients have become essential in both cosmetic and dermatological formulations. Among them, PDRN (Polydeoxyribonucleotide) is widely known for its regenerative properties and has been traditionally sourced from salmon DNA. CICA PDRN, a new, plant-derived version, extracted from Centella asiatica is redefining skin-repair solutions with a cleaner, vegan-friendly, and more sustainable profile.

What Is PDRN?

PDRN is a DNA polymer composed of nucleotides (50–1,500 kDa) that helps stimulate tissue repair, improve cell turnover, and enhance wound healing. In dermatology, PDRN is used in injections, topical ampoules, and regenerative skincare due to its ability to:

- Promote fibroblast activity

- Boost collagen synthesis

- Accelerate tissue renewal

- Reduce inflammation

Traditionally, PDRN has been sourced from salmon sperm extracts, limiting its use among individuals seeking vegan or allergen-free alternatives.

What Is CICA PDRN?

CICA PDRN is a plant-derived form of PDRN that uses DNA fragments extracted from the Centella asiatica plant, also known as “CICA.” Centella asiatica is already well-known for its healing components"Madecassoside, Asiaticoside, Asiatic Acid, and Madecassic Acid".

Key Benefits of CICA PDRN

1. Skin Regeneration and Repair

CICA PDRN stimulates cell proliferation and encourages skin tissue renewal. It supports:

- Faster recovery from irritation

- Strengthening of damaged skin barrier

- Improved recovery after dermatological procedures

2. Collagen Synthesis

The DNA fragments promote fibroblast activity, helping the skin produce new collagen. This leads to:

- Firmer, more elastic skin

- Smoother and more youthful texture

3. Anti-Inflammation

Centella asiatica naturally reduces inflammation. Combined with PDRN’s regenerative qualities, CICA PDRN:

- Reduces redness

- Calms irritated or acne-prone skin

- Helps with post-laser or post-peel sensitivity